Best of
Best TMG Supplement: Dose, Purity and Price Compared
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We don't sell supplements; brands can't pay for placement; rankings use published testing and price per daily dose. How we rank
Independent of the brands we list: commission never changes a ranking. How we choose: form and dose, independent testing, ingredients and price per serving.
Affiliate disclosure: some links on this page are affiliate links. If you buy through them we may earn a commission at no extra cost to you. Commission never changes how we rank products. This is general information, not medical advice.
TMG, also called betaine or trimethylglycine, is a compound found in foods such as sugar beet. In trials, at least 4 g a day for 6 or more weeks lowered homocysteine, a blood marker. The same doses raised total and LDL cholesterol in some analyses, and we found no trial showing that lowering homocysteine with TMG improves health outcomes. We rate the evidence C. Read the TMG guide first. This page compares the three TMG products we have price and label data for, and the US offers are the ones we priced most fully.
Short answer: Best budget (US$): Nutricost Betaine Anhydrous (TMG) powder ($0.036 a gram); tablets: NOW TMG 1,000 mg (US$); capsules with a UK offer: Life Extension TMG 500 mg (US$ and £). No product has a named testing program in our data, so there is no Best overall. Prices, testing and every shop are in the picks below.
Quick picks
| Pick | Product | Best for | Price | Buy |
|---|---|---|---|---|
| Best budget (US$) | Betaine anhydrous (TMG) powder, 500 g | Readers paying in dollars who want the lowest price per gram | $0.036 per 1 g TMG ($17.97 ÷ 333 servings × 1 ÷ 1.5 g; checked Nov 3, 2026 at Nutricost) | Nutricost (affiliate link) |
| Tablets (US$) | TMG 1,000 mg, 100 tablets | Readers paying in dollars who prefer tablets from a widely sold brand | $0.283 per 1 g TMG ($27.99 ÷ 33 servings × 1 ÷ 3 g; checked Nov 3, 2026 at NOW Foods) | NOW Foods (affiliate link) +2 more |
| Only product with a UK price | TMG 500 mg, 60 liquid vegetarian capsules | Readers who want capsules, including UK readers | $0.338 per 1 g TMG ($10.13 ÷ 30 servings; checked Nov 3, 2026 at Life Extension) | Life Extension (affiliate link) +1 more |
Our ranked picks
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Best budget (US$)
Betaine anhydrous (TMG) powder, 500 g
Betaine anhydrous (TMG) powder, 500 g; one scoop is 1.5 g, about 333 servings.
Pros
- Lowest price per gram on this page, by a wide margin
- Powder, so there are no capsules to count
Cons
- The brand says its products are tested by independent labs, but no certificate is named, so we do not count it
- One shop in our data
- About 2.7 scoops reach 4 g
United States
-
Tablets (US$)
TMG 1,000 mg, 100 tablets
TMG tablets, 1,000 mg each, 100 tablets; the label serving is 3 tablets (3 g), 33 servings.
Pros
- Label serving of 3 g
- Three shops listed (NOW, iHerb and Amazon.com)
Cons
- About eight times Nutricost's price per gram
- Intertek GMP certification is a facility certification, not batch testing, so we do not count it
- The iHerb and Amazon.com prices are not captured
United States
Worldwide
- Intl Check price at iHerb
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Only product with a UK price
TMG 500 mg, 60 liquid vegetarian capsules
TMG liquid vegetarian capsules, 500 mg each; 2 capsules give 1 g, 60 capsules.
Pros
- Capsules
- Prices in both dollars (Life Extension) and pounds (Welzo)
Cons
- No testing named in our data
- Capsules are the costliest form per gram here, and 4 g would take 8 capsules
- Welzo is the only UK offer in our data
United States
United Kingdom
- UK Buy at Welzo
How we rank
We only rank products that are in our product data file, and we use only what that file records:
- Form and amount. One product is a powder (Nutricost), one is tablets (NOW) and one is capsules (Life Extension), all TMG or betaine anhydrous. Serving sizes differ: 1.5 g, 3 g and 1 g. We compare the grams of TMG per serving and scale every price to 1 g.
- Third-party testing, as listed. We note a named testing program (for example NSF Certified for Sport) when our data lists one. Where the data says “brand statement”, we say so and do not count it as verified by us.
- Price per daily dose. We divide the pack price by the servings per pack, then scale to our basis: 1 g of TMG (betaine anhydrous). Most trials used at least 4 g a day, so multiply by 4 for that amount. It is a price basis, not a recommended dose. Prices in different currencies are not converted, so $ and £ are only compared within their own currency.
Winner labels. “Best overall” goes to the cheapest product with a named testing program in that currency. “Best budget” goes to the lowest price per daily dose in that currency, whatever the testing. “Best tested” is only used when one product lists clearly more named programs than the rest. If no product qualifies for a label, we leave that label out.
Most trials used more. Trials used at least 4 g a day, so a daily cost is about four times the per-gram price: Nutricost $0.144, NOW $1.13 and Life Extension $1.35 in dollars, or £1.56 at Welzo. These are arithmetic, not a recommendation to take 4 g.
No Best overall. No product lists a named third-party testing program, so we award only Best budget in dollars. Welzo is the only UK offer, so there is no UK ranking.
What we did not do. We have not tested these products ourselves, in a lab or by taking them. We did not rank by commission. Prices change, so each price shows the date it was checked. More in How we rank.
Price per daily dose
Basis: 1 g of TMG (betaine anhydrous). Most trials used at least 4 g a day, so multiply by 4 for that amount. It is a price basis, not a recommended dose. Every number below is worked out from the pack price, servings per pack and amount per serving in our product data.
US dollar prices ($)
| Product (retailer) | Amount per serving | Pack price (checked) | Price per serving | Price per daily dose | Testing named in our data |
|---|---|---|---|---|---|
| Nutricost Betaine anhydrous (TMG) powder, 500 g (Nutricost) | 1.5 g TMG per scoop | $17.97 (Nov 3, 2026) | $17.97 ÷ 333 = $0.054 | $0.054 × 1 ÷ 1.5 = $0.036 | None named |
| NOW Foods TMG 1,000 mg, 100 tablets (NOW Foods) | 3 tablets: 3 g TMG (1,000 mg per tablet) | $27.99 (Nov 3, 2026) | $27.99 ÷ 33 = $0.848 | $0.848 × 1 ÷ 3 = $0.283 | None named |
| Life Extension TMG 500 mg, 60 liquid vegetarian capsules (Life Extension) | 2 capsules: 1,000 mg TMG (500 mg per capsule) | $10.13 (Nov 3, 2026) | $10.13 ÷ 30 = $0.338 | $0.338 | None named |
UK prices (£)
| Product (retailer) | Amount per serving | Pack price (checked) | Price per serving | Price per daily dose | Testing named in our data |
|---|---|---|---|---|---|
| Life Extension TMG 500 mg, 60 liquid vegetarian capsules (Welzo) | 2 capsules: 1,000 mg TMG (500 mg per capsule) | £11.73 (Nov 3, 2026) | £11.73 ÷ 30 = £0.391 | £0.391 | None named |
The price per 4 g shown above is the per-gram price times 4, from the same data. The same doses raised cholesterol in some analyses, so read the TMG guide before choosing an amount.
How to start
Most trials used at least 4 g a day for homocysteine and lasted 6 to 24 weeks. Those are study amounts, not recommendations, and long-term effects are unknown. The same doses raised cholesterol in some analyses, so ask a doctor or pharmacist before trying it. The labels here give 1 g (Life Extension, per 2 capsules), 1.5 g (Nutricost, per scoop) or 3 g (NOW, per 3 tablets) per serving. See the TMG guide.
Talk to your doctor or pharmacist
Talk to your doctor or pharmacist before you start any supplement, especially if you are pregnant or breastfeeding, take prescription medicine, or have a health condition. This matters especially if you have high cholesterol or heart risk, because the doses used in trials raised total and LDL cholesterol in some analyses. The full guide has the evidence, safety notes and citations.
How we chose
We compared three TMG (betaine anhydrous) products by grams per serving, form, named testing and price per gram. We have not tested any product ourselves, and commission does not affect the order.
FAQ
What is the best TMG supplement?
From our data: Nutricost’s powder has the lowest price per gram in dollars. None of the three lists a named testing program, so the label and your own check of the grams per serving matter most.
Does TMG raise cholesterol?
In some analyses, doses of 4 g a day or more raised total and LDL cholesterol. See the guide for the studies.
How many capsules is 4 g of TMG?
It depends on the product: 8 Life Extension capsules (500 mg each), about 4 NOW tablets (1,000 mg each) or about 2.7 Nutricost scoops (1.5 g each). Studies used 4 g or more a day, which is a study amount, not a recommendation.
What names does TMG go by on labels?
TMG, trimethylglycine and betaine anhydrous. The products here use the names TMG or betaine anhydrous; check that the label states the grams of TMG per serving.
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Medical disclaimer