Best CoQ10 Supplement: Ubiquinone vs Ubiquinol, Compared

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CoQ10 is a substance your body makes and uses to produce energy inside cells. Most supplement trials were in people with health conditions, not healthy adults, and the results are mixed, so we rate the evidence C. A large heart failure trial found fewer serious heart events, but a Cochrane review judged there is still no convincing evidence either way, and it did not meaningfully change blood pressure. Small trials suggest it may ease muscle aches in people taking statins. Read the CoQ10 guide first, then use this page to compare the four products we have price and label data for.

Short answer: Best overall (US$) and Best budget (US$): Doctor’s Best High Absorption CoQ10 (USP Verified as stated by the brand; stock unconfirmed); confirmed testing listing: Thorne CoQ10 (NSF Contents Certified, US$); ubiquinol: Life Extension Super Ubiquinol (US$); UK: Healthspan Ubiquinol is the only product with a UK price. Prices, testing and every shop are in the picks below.

How we rank

We only rank products that are in our product data file, and we use only what that file records:

1. Form and amount. Two products are ubiquinone (Thorne and Doctor’s Best) and two are ubiquinol (Life Extension and Healthspan), each with 100 mg of CoQ10 per serving. We did not find a verified head-to-head comparison of the two forms, so we don’t rank one form above the other. We compare the mg of CoQ10 itself.
2. Third-party testing, as listed. We note a named testing program (for example NSF Certified for Sport) when our data lists one. Where the data says “brand statement”, we say so and do not count it as verified by us.
3. Price per daily dose. We divide the pack price by the servings per pack, then scale to our basis: 100 mg of CoQ10 (ubiquinone or ubiquinol) a day, which is 1 serving of each product. It is a price basis, not a recommended dose. Prices in different currencies are not converted, so $ and £ are only compared within their own currency.

Winner labels. “Best overall” goes to the cheapest product with a named testing program in that currency. “Best budget” goes to the lowest price per daily dose in that currency, whatever the testing. “Best tested” is only used when one product lists clearly more named programs than the rest. If no product qualifies for a label, we leave that label out.

Testing claims differ in strength. Thorne’s NSF Contents Certified listing was found in NSF’s directory. Doctor’s Best’s USP Verified claim is stated on its own page, and we did not open the USP directory. By our rule (cheapest product with a named program) Doctor’s Best takes Best overall in dollars on that stated claim; if you want the listing we confirmed, Thorne is the pick, at about five times the price.

Unverified prices. Where a price was read through a search tool instead of on the shop’s own page (Thorne at Amazon.com), the table says so and no pick relies on it.

UK. Healthspan is the only product with a UK price, so there is no UK ranking, only one option.

What we did not do. We have not tested these products ourselves, in a lab or by taking them. We did not rank by commission. Prices change, so each price shows the date it was checked. More in How we rank.

Price per daily dose

Basis: 100 mg of CoQ10 (ubiquinone or ubiquinol) a day, which is 1 serving of each product. It is a price basis, not a recommended dose. Every number below is worked out from the pack price, servings per pack and amount per serving in our product data.

US dollar prices ($)

Product (retailer)	Amount per serving	Pack price (checked)	Price per serving	Price per daily dose	Testing named in our data
Doctor’s Best High Absorption CoQ10 100 mg with BioPerine, 120 softgels (Doctor’s Best)	1 softgel: 100 mg CoQ10 (ubiquinone) + 5 mg BioPerine (black pepper extract, 95% piperine)	$20.99 (Nov 3, 2026)	$20.99 ÷ 120 = $0.175	$0.175	USP Verified (stated on the Doctor’s Best product page; the USP directory listing was not opened)
Life Extension Super Ubiquinol CoQ10 100 mg, 60 softgels (Life Extension)	1 softgel: 100 mg ubiquinol (Kaneka)	$37.50 (Nov 3, 2026)	$37.50 ÷ 60 = $0.625	$0.625	None named
Thorne CoQ10 100 mg (ubiquinone), 60 gelcaps (Thorne)	1 gelcap: 100 mg CoQ10 (ubiquinone)	$53.00 (Nov 3, 2026)	$53.00 ÷ 60 = $0.883	$0.883	NSF Contents Certified (Thorne CoQ10 is listed in NSF’s certified dietary supplement directory; the NSF listing shows a 2-gelcap serving, so check the pack; not the NSF Certified for Sport program)
Thorne CoQ10 100 mg (ubiquinone), 60 gelcaps (Amazon.com)	1 gelcap: 100 mg CoQ10 (ubiquinone)	$53.00 (Nov 3, 2026; price read through a search tool, not on the shop page)	$53.00 ÷ 60 = $0.883	$0.883	NSF Contents Certified (Thorne CoQ10 is listed in NSF’s certified dietary supplement directory; the NSF listing shows a 2-gelcap serving, so check the pack; not the NSF Certified for Sport program)

UK prices (£)

Product (retailer)	Amount per serving	Pack price (checked)	Price per serving	Price per daily dose	Testing named in our data
Healthspan Ubiquinol 100 mg (Kaneka), 60 vegan capsules (Healthspan)	1 capsule: 100 mg ubiquinol (Kaneka) with vitamins B1 and E	£46.99 (Nov 3, 2026)	£46.99 ÷ 60 = £0.783	£0.783	None named

Doctor’s Best’s price is for 120 softgels. The brand page showed a Sold out button when we checked on Nov 3, 2026, so recheck stock before you plan around it.

How to start

Studies have used 100 mg three times a day (300 mg a day) in heart failure on top of usual care, and 100 to 600 mg a day for 30 to 90 days in statin muscle trials. Those are study amounts, not recommendations. All four products here give 100 mg of CoQ10 per serving. CoQ10 is fat-soluble, but we found no verified study on whether taking it with food matters. See the CoQ10 guide.

Talk to your doctor or pharmacist

Talk to your doctor or pharmacist before you start any supplement, especially if you are pregnant or breastfeeding, take prescription medicine, or have a health condition. Do not change or stop heart medicines or statins because of a supplement. Tell your anticoagulant clinic before starting if you take warfarin. Doctor’s Best also contains BioPerine (piperine), which can change how some medicines are absorbed. The full guide has the evidence, safety notes and citations.